The international research team under the leadership of the University of Würzburg (Germany) has revealed an important mechanism that cells use to remove harmful protein clusters. These proteins stimulate the growth of various neurodeless diseases. The study was published in the Journal of Natural Communication Science (NATCOMS).
The team found that the P97/VCP enzyme (Anprintaz by Kilquin analysis) plays a central role in destroying protein units called intensity. The accumulation of inaccurate curled proteins is formed with neurodegenerative diseases and is usually removed by a cell. However, if P97/VCP is blocked, the cleaning process is disturbed, leading to the accumulation of toxic sediments.
Without this enzyme, the focus is not divided into smaller components and is not displayed. This may be one of the reasons for the progression of protein -related diseases, he explained the leading author of Alexander Bhabberger.
The mutation in P97/VCP has been called the cause of some forms of dementia and muscle atrophy (BAS). In the case of Parkinson's disease in neurons, Taurus's taxes – accumulating protein, as suggested by scientists, may be “unstable”. The new data confirms that P97/VCP dysfunction contributes to the development of these pathologies, violates the process of natural cell treatment. Discover opens the way to develop drugs that can activate P97/VCP to enhance the decline of harmful proteins.